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A stretch of the major road near Witney has been closed in both directions while authorities attempt to help the injured and clear the debris.
Queues of almost two miles are reported at the scene.
The woman is deemed to have life-threatening injuries while the man's condition is serious but not life-threatening.
Up to 15 others are being treated at the scene for minor injuries.
(Tunbridge Wells, Kent)Professor Nigel Leslie Brown, FRSE. Group manager for Debt Contact Centres, Debt Management, Department for Work and Pensions. For services to Further Education for Young Adults with Complex Disabilities and Severe Learning Difficulties. For services to Psychiatry and for voluntary service to People with Mental Health Conditions. For services to Search and Rescue in the UK and Abroad. For public service and for services to the community in Northern Ireland. For services to Higher Education and to the Royal National Lifeboat Institution. For services to research and agriculture in the Falkland Islands. Executive chairman, China Food Company plc, Non-Executive director, China Britain Business Council, and Chair, VSO China.
Ms Hennell, known as 'Connie', who was on first-name terms with all the prime ministers she worked for, first heard of her nomination - made at Prime Minister David Cameron's recommendation - by letter in November. For services to Education and voluntary service to People with Disabilities. Deputy Principal, EU and Employment Relations Division, Department for Employment and Learning, Northern Ireland Executive. For services to the Church of England particularly the Preservation of the Built Heritage of Churches through the Diocesan Advisory Committee in Lancashire. Senior Officer, Operational Delivery Profession, Development and Capability manager, HM Revenue and Customs. (Newcastle, Tyne and Wear)Mrs Alison Lynda Middleton, JP.A woman has died following a huge pile-up on the A40 near Witney, Oxfordshire, involving up to 20 vehicles.Two other people – a man and a woman – have been taken to hospital.It was like glass.” He said a woman had run along the embankment waving at drivers to slow down as they approached the crash site.This allowed him to slow his lorry down enough to avoid hitting the car in front – something he said could have made the accident much worse.
Miss Keith, who has already received an OBE and a CBE, added: ‘I sort of feel elated, exhausted and thrilled. I don’t know what is better than the icing on the cake, but this is.’ ‘To accept such an award after only a decade of service to music and charity comes as a wonderful surprise,’ she said. Librarian and director general, Information Services, House of Commons. For services to International Development and Humanitarian Assistance in Pakistan. For services to Mediation in the Workplace and to the community in West Lothian. Lead Professional Dietician and Allied Health Professions Lead for Hospital Services, South Eastern Trust. Senior Adviser, Verde Xchange Institute and Member, Board of Governors, Los Angeles County Economic Development Corporation, USA.